The scheme at 140 Wales Farm Road on the former Perfume Factory site will contain 600 student rooms and 85 PRS residential units.
Work will include construction of a series of blocks rising to 31-storeys.
Ardmore’s managing director, Cormac Byrne, said: “We are delighted to have been appointed as the main contractor for this important project.
“I am especially pleased that Imperial College have shown such confidence in us to deliver one of their most prestigious schemes.
“140 Wales Farm Road will be the tallest traditional masonry tower in the UK, and its unique design provides several challenges; not least providing external façade access at 31-storeys via an innovative climbing screen.
“We look forward to working with Imperial College and their team to tackle these challenges head on and deliver some of the best student accommodation in London.”